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Welcome to the Integrated Chemical
Environment, also known as ICE.

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In this video, we will provide a brief

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introduction to the
ICE Curve Surfer tool.

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Other videos explain in detail how
to set up a query using the ICE

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Curve Surfer tool, and how
to view and save query results.

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The ICE Curve Surfer tool allows you to

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view and interact with concentration-response curves

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from the in vitro high-throughput

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screening data in ICE
that has been curated by NICEATM.

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This tool allows users to input one or
more chemicals or assays to view a set

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of concentration-response curves
that can be sorted and filtered.

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Both graphics and data can be exported

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to save or to build additional
queries in ICE or other resources.

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Each graph
viewed in the Curve Surfer query results

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landing page is a single chemical-assay concentration-response curve.

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Each graph is accompanied by information
that can help contextualize the curve:

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the AC50 informs on the chemical's potency

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in the assay, while the top of curve
informs on the chemical's efficacy.

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Mechanistic target annotations

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for the assay are also provided
to facilitate interpretation.

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Several options are provided to organize
Curve Surfer query results.

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Large queries may span multiple pages
and can be sorted and filtered.

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You can also overlay several concentration

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curves of interest to view
them all on one plot.

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Located throughout the tool are green

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information buttons to help you better
understand key features and results.

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When you hover over a button,
brief explanatory text will appear.

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When you click a button,
more details will appear in a text box

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that can be relocated on the screen
for a clearer field of vision.

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If you encounter a problem using a tool,
click the "Report an Issue" button

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on the left side of the display
to generate an email to ICE Support.

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Thank you for watching our introduction
video for the Curve Surfer tool in ICE.

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For more detailed information on the tool,
go to "Help" and select "User Guides."