WEBVTT

1
00:00:00.200 --> 00:00:04.220
Welcome to the Integrated Chemical
Environment, also known as ICE.

2
00:00:04.250 --> 00:00:09.300
In this video, we will provide a brief
overview of the ICE PBPK tool.

3
00:00:09.330 --> 00:00:15.240
Other videos explain in detail how to set
up a query using the ICE PBPK tool and how

4
00:00:15.270 --> 00:00:19.900
to interpret the output
of a PBPK tool query.

5
00:00:19.920 --> 00:00:22.220
Physiologically based pharmacokinetic

6
00:00:22.240 --> 00:00:27.060
models, or PBPK models,
are mathematical representations

7
00:00:27.080 --> 00:00:32.540
of a chemical's ADME characteristics:
how the chemical is absorbed, distributed,

8
00:00:32.570 --> 00:00:37.060
metabolized, and excreted
in the body of a human or animal.

9
00:00:37.090 --> 00:00:39.740
PBPK models have multiple compartments

10
00:00:39.770 --> 00:00:44.300
that can represent blood plasma,
organs or organ systems.

11
00:00:44.330 --> 00:00:48.300
These models can be used in many
applications when you need to relate

12
00:00:48.330 --> 00:00:52.300
an external exposure
to an internal concentration.

13
00:00:52.330 --> 00:00:57.780
The ICE PBPK tool allows you to generate
predictions of tissue-specific chemical

14
00:00:57.810 --> 00:01:01.460
concentration profiles
following an external exposure.

15
00:01:01.490 --> 00:01:04.290
The profiles are generated using the PBPK

16
00:01:04.320 --> 00:01:08.740
models from the httk R
package developed by the U.S.

17
00:01:08.770 --> 00:01:11.050
Environmental Protection Agency.

18
00:01:11.080 --> 00:01:16.100
To run the Ice PBPK tool,
you need to specify dose amount,

19
00:01:16.130 --> 00:01:21.740
exposure route, exposure frequency,
and simulation length.

20
00:01:21.770 --> 00:01:24.540
The tool output provides the chemical

21
00:01:24.570 --> 00:01:28.420
concentration in the modeled
tissue compartments over time.

22
00:01:28.450 --> 00:01:31.180
These outputs include Cmax,

23
00:01:31.210 --> 00:01:36.140
the maximum concentration of the chemical
in each compartment, and Css,

24
00:01:36.170 --> 00:01:40.210
the concentration of the
chemical at steady state.

25
00:01:40.240 --> 00:01:42.290
Located throughout the tool are green

26
00:01:42.320 --> 00:01:46.820
information buttons to help you better
understand key features and results.

27
00:01:46.850 --> 00:01:51.570
When you hover over a button,
brief explanatory text will appear.

28
00:01:51.600 --> 00:01:55.260
When you click a button,
more details will appear in a text box

29
00:01:55.290 --> 00:01:58.780
that can be moved on the
screen for a clearer view.

30
00:01:58.810 --> 00:02:03.260
If you encounter a problem using a tool,
click the "Report an Issue" button

31
00:02:03.290 --> 00:02:07.780
on the left side of the display to send
an email to ICE support.

32
00:02:07.810 --> 00:02:12.540
Thank you for watching our overview
video on the PBPK tool in ICE.

33
00:02:12.570 --> 00:02:17.280
For more detailed information about the
tool, go to "Help" and select "User Guides."