WEBVTT

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Welcome to the Integrated Chemical
Environment, also known as ICE.

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In this video, we will provide a brief
overview of the ICE PBPK

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(or physiologically based
pharmacokinetic) tool.

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Other videos explain in detail how to set
up a query using the ICE PBPK tool and how

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to interpret the output
of a PBPK tool query.

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PBPK models are mathematical
representations of a chemical's ADME

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characteristics:
how the chemical is absorbed, distributed,

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metabolized, and excreted
in the body of a human or animal.

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PBPK models consist of multiple
compartments that represent

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arterial and venous compartments,
specific organs or organ systems.

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These models can be used in many
applications

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when you need to relate an external
exposure to internal concentrations.

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The ICE PBPK tool allows you to generate
predictions of dynamic tissue-specific

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chemical concentration profiles
following an external exposure.

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The profiles are
generated using various PBPK

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models from the httk R package,
which was developed by the

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U.S. Environmental Protection Agency.

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To run the ICE PBPK
tool, you'll need to specify species,

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body weight, ADME source, dose amount,
exposure route, exposure interval,

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and simulation length.

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The tool output provides the chemical
concentration in the model

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tissue compartments over time.

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These outputs include Cmax,
the maximum concentration of the chemical

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in each compartment, and Css,
the concentration

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of chemical at steady state.

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Located throughout the tool are green
information buttons to help you better

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understand key features and results.

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When you hover over a button,
brief explanatory text will appear.

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When you click a button,
more details will appear in a text box

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that can be moved on the
screen for a clearer view.

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If you encounter a problem using a tool,
click the "Report an Issue" button

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on the left side of the display
to send an email to ICE Support.

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Thank you for watching our overview
video on the PBPK tool in ICE.

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For more detailed information about the
tool, go to "Help" and select "User Guide".