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To run a search, you must specify at least

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one assay or chemical or
a combination of both.

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You can add chemicals to your query using

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one or both of the input methods
in the chemical input field on the left

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side of the screen so you can enter your
own chemical and it fires one pair row.

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For example, we can type 50-28-2 the CASRN for the chemical estradiol

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for this video we have a list

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of Identifiers also that we
gather from the EPA.

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Com Tax Chemical Dashboard.

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I'm going to copy those and also
paste them here one per row.

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You can use any combination
of the following Identifiers casrn,

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DTXSIDS, smiles and inchi keys.

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ICE also gives you the option of using

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Chemical Quick List,
which are list of chemicals that have been

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found useful for evaluating
specific types of toxicities.

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For the search.

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In addition to the estradiol and other
identifiers will add the skin corrosion

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and reference Chemical Quick
list to the query.

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You can run the search in ICE
without specifying chemicals.

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If you don't, your results will include

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all chemicals with data for
your specified assay.

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Now to add assays,

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click on the select assays from the assay
input in the dialog box that appears.

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Select a category of interest
from the tab and then select the assays

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and end points of interest
in the window that opens.

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For example, we're going to select acute

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lethality say type,
and select all the dermal,

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and inhalation endpoints,

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we can also open the mode of action
drop down and select some or all of them.

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And if I want more information on this

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asset grouping, I will either just hover
over here or open the information box.

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Now you can use the check boxes here also
to select or unselect the selections.

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You must specify at least
one assay to run a query.

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If not, your results will include all

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assays with data for the
specified chemicals.

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Before you run the search, let's look
at two more options provided by ICE.

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On the bottom, you will see
that we have an option.

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Add chemicals with identical
QSAR structures.

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Checking this box will add chemicals

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available in ICE to your query that have
the same QSAR structure as a chemical you

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have specified, for example,
different salts of the same compound.

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For this video,
we will select this option.

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ICE also gives you two options
to define the scope of the search.

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The default option Union, results all

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assays available in ICE for all chemicals
specified in the search,

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the more restrictive option Intersection
returns assays results only for chemicals

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that are tested in all
the selected assays.

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Now that you have built your query,

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you can run your search
and look at the results.

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Thank you for watching our video
on how to build a search query in ICE.

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For more detailed information

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of the search tool, go to help
and select user guides.